Combination inhibition activity of chlorhexidine and antibiotics on multidrug-resistant Acinetobacter baumannii in vitro

Abstract Background Chlorhexidine is a widely used disinfectant in clinical settings and broad-spectrum antimicrobial agent effective against aerobic anaerobic bacteria. However, resistant or non-susceptible bacteria, including antibiotic-resistant Acinetobacter baumannii, have been found. This study aimed to develop new technique prevent control A. baumannii infection the hospital setting. Methods combined with minocycline, doxycycline, meropenem, imipenem, levofloxacin ciprofloxacin were tested 30 multidrug-resistant extremely drug-resistant isolates. The checkerboard test was calculate fractional inhibitory concentration index according minimum value for chlorhexidine antibiotics. Results combination of showed synergistic responses all isolates, more than 50% isolates FICI ?0.5. together imipenem indifferent 10% 3.33% respectively. In tests, combinations each above six antibiotics additive effects, inhibited Conclusions We concluded that, could be risk .